Pesticides Usage and Its Toxic Effects – A Review


  • Prerna Sood Department of Zoology, College of Basic Sciences and Humanities, Punjab Agricultural University, Ludhiana 141004, Punjab



Human health, pesticides environment, agriculture, toxicity, india, biopesticides, humans, weeds, diseases, insecticides


The urbanization of agriculture sector leads to an increased chemical affliction on the environment. Pesticides are the chemicals used in agriculture to protect the plants from weeds, pests or diseases and human being from various diseases. In this review, the literature of different types of pesticides, pesticide usage and its toxic effects on mammalian systems are summarized. Most commonly used pesticides are fungicides, insecticides and herbicides to control the weeds and pest from agricultural sites. In the usage of pesticides, India stands 12th in the world even though the use of pesticides in India is low as compared to other nations in the world. However due to their negative impacts on human and the environment there is a requirement for an ecological and sustainable approach, as the public needs the execution of the latest concept of agriculture that is safe for humans and the environment. For the sustainable agriculture development and to protect the environment from adverse effects of chemical pesticides, formulation and utilisation of bio-pesticides should be encouraged.


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How to Cite

Sood, P. . (2023). Pesticides Usage and Its Toxic Effects – A Review. Indian Journal of Entomology, 86(1), 339–347.



Review Articles


Aggarwal A and Sharma B. 2010. Pesticide induced oxidative stress in mammalian systems: Review article. International Journal of Biological and Medical Research 1: 90-104.

Akashe M M, Pawade U V, Nikam A V. 2018. Classification of pesticides: a review. International Journal of Research in Ayurveda and Pharmacy 9(4): 144-150.

Alewu B, Nosiri C. 1990. Pesticides and human health: Public health impact of pesticides used in agriculture. Stoytcheva M. England: World Health Organization. 133 pp.

Amal A M, Howaida A N, Gihan M, Sharara M H Abdel A. 2005. Role of oxidative stress and apoptosis into acute organophosphorus intoxicated patients. Journal of Medical Research Institute 26: 255-263.

Archana R, Sahai A, Srivastava A K, Rani A. 2007. Carbaryl induced histopathological changes in the testis of albino rats. Journal of the Anatomical Society of India 56: 4-6

Azmi M A, Azmi N M A, Aslam, M. 2006. Effect of pesticide on health and different enzymes levels in the blood of farm workers from Gadap (rural area) Karachi- Pakistan. Chemosphere 64(10): 1739-44.

Banerjee B D, Seth V, Bhattacharya A, Pasha S T and Chakrborty A K. 1999. Biochemical effects of some pesticides on lipid peroxidation and free radical scavengers. Toxicological Letters 107: 33-47.

Bannen K C, Devaud L L, Liu J P and Lauder J M. 1998. Prenatal exposure to neuro toxicants dieldrin or lindane alters tert-butyl-bicyclophosphorothionate binding to GABAA receptors in fetal rat brain stem. Neuroscience 201: 34-41.

Bharadwaj J K and Saraf P. 2014. Influence of toxic chemicals on female reproduction: A review. Cell Biology: Research and Therapy Journal 3: 1.

Bhardwaj T and Sharma J P. 2013. Impact of pesticides application in agricultural industry: An Indian scenario, International Journal of Agriculture and Food Science Technology l4 (8): 817-822.

Birnbaum L S, Fenton S E. 2003. Cancer and developmental exposure to endocrine disruptors. Environment Health Perspectives 111: 389-394.

Calle E E, Frumkin H, Henley S J, Savitz D A, Thun M J. 2002. Organochlorines and breast cancer risk. CA A Cancer Journal for Clinicians 52: 301-9.

Chourasiya S, Khillare P S, Jyethi D S. 2015. Health risk assessment of organochlorine pesticide exposure through dietary intake of vegetables grown in the peri urban sites of Delhi, India. Environment Science and Pollution Research 22: 793-806.

Debost-Legrand A, Warembourg C, Massart C, Chevrier C, Bonvallot N, Monfort C, Rouget F, Bonnet F, Cordier S. 2016. Prenatal exposure to persistent organic pollutants and organophosphate pesticides, and markers of glucose metabolism at birth. Environment Research 146: 207-217.

Devi P I. 2010. Pesticides in agriculture- boon or a curse? A case study of Kerala. Economic and Political Weekly 45: 26-27.

FAO. 2018. Pesticide Use Data-FAOSTAT. #data/RP.

FOCUS 2008. Pesticides in air: Considerations for Exposure assessment. Report. Working Group on Pesticides in Air, EC Document Reference SANCO/10553/2006.

Freire C, Koifman R J, Koifman S. 2015. Hematological and hepatic alterations in brazilian population heavily exposed to organochlorine pesticides. Journal of Toxicology and Environment Health 78: 534-48.

Garey J, Wolff M S. 1998. Estrogenic and antiprogestagenic activities of pyrethroid insecticides. Biochemical Biophysical Research Communication 251: 855-859.

Gasnier C, Dumont C, Benachour N, Clair E, Chagnon M C, Séralini G E. 2009. Glyphosate-based herbicides are toxic and endocrine disruptors in human cell lines. Toxicology 262: 184-91.

Ghosh P K and Philip L. 2006. Environmental significance of atrazine in aqueous systems and its removal by biological processes: An overview. Global NEST Journal 8(2): 159-78.

Ghuman S P S, Ratnakaran U, Bedi J S, Gill J P S. 2013. Impact of pesticide residues on fertility of dairy animals: A review. The Indian Journal of Animal Sciences 83: 1243-1255.

GOI, 2021. Insecticides /pesticides registered under section 9(3) of the Insecticides Act, 1968. for use in the country.

Goldman J M, Stoker T E, Cooper R L, McElroy W K, Hein J F. 1994. Blockade of ovulation in the rat by the fungicide sodium N-methyldithiocarbamate: relationship between effects on the luteinizing hormone surge and alterations in hypothalamic catecholamines. Neurotoxicological Teratology 16: 257-268.

Goldman L, Falk H, Landrigan, P J, Balk, S J, Reigart R, Etzel R A. 2004. Environmental pediatrics and its impact on government health policy. Pediatrics 113: 1146-1157.

Hernandez F A, Gomez M A, Perez V G, Lario V J, Pena G Gill F. 2006. Influence of exposure to pesticides on serum components and enzyme activities of cytotoxicity among intensive agricultural farmers. Environment Research 102:70-76.

Henderson P T, Borm P J A, Kant I J. 1995.Basis boek Arbeidstoxicologierisicoinventarisatie en -evaluatieZeist: UitgeverijKerckeboschbv.

Hodges L C, Bergerson J S, Hunter D S, Walker C L. 2000. Estrogenic effects of organochlorine pesticides on uterine leiomyoma cells in vitro. Toxicological Science 54: 355-364.

Jaga K, Dharmani C. 2003. Sources of exposure to and public health implications of organophosphate pesticides. Reviews of Panam Salud Publications 14: 171-85.

Jamal F, Haque Q S, Singh S, Rastogi S. 2015. The influence of organophosphate and carbamate on sperm chromatin and reproductive hormones among pesticide sprayers. Toxicological Industrial Health: 1-10.

Kalender S, Kalender Y, Durak D, Ogutcu A, Uzunhisarcikli M, Cevrimli B S and Yildirim M .2007. Methyl parathion induced nephrotoxicity in male rats and protective role of vitamins C and E. Pesticide Biochemistry and Physiology 88: 213-18.

Karami-Mohajeri S, Abdollahi M. 2011.Toxic influence of organophosphate, carbamate, and organochlorine pesticides on cellular metabolism of lipids, proteins, and carbohydrates: a systematic review. Human Experimental Toxicology 30(9): 1119-40.

Lee D H, Lind P M, Jacobs D R, Salihovic S, Van Bavel B, Lind L. 2011. Polychlorinated bis phenyls and organochlorine pesticides in plasma predict development of type 2 diabetes in the elderly. The Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. Diabetes Care 34:1778-1784.

Lemaire G, Terouanne B, Mauvais P, Michel S, Rahman R. 2004. Of organo-chlorine pesticides on human androgen receptor activation in vitro. Toxicological and Applied Pharmacology 196: 235-46.

Li D, Huang Q, Lu M, Zhang L, Yang Z, Zong M. 2015. The organophosphate insecticide chlorpyrifos confers its genotoxic effects by inducing DNA damage and cell apoptosis. Chemosphere 135: 387-93.

Li Q, Kobayashi M, Kawada T. 2011. Ziram induces apoptosis and necrosis in human immune cells. Archives of Toxicology 85: 355-61.

Lifshitz M, Shahak E, Bolotin A, Sofer S. 1997. Carbamate poisoning in early childhood and in adults. Journal of Toxicology and Clinical Toxicology 35: 25-7. Maellaro E, Casini F, Del Bello B, Comporti M. 1990. Lipid peroxidation and antioxidant systems in the liver injury produced by glutathione depleting agents. Biochemical Pharmacology 39: 1513-1521.

Matthews G (ed). 2015. Pesticides: health, safety and the environment, 2nd edn. Wiley, New York. ISBN 978-1-118-97602-9.

McGill A E, Robinson J. 1968. Organochlorine insecticide residues in complete prepared meals: a 12-month survey in S.E. England. Food and Cosmetics Toxicology 6: 45-57.

McLachlan J A. 2001. Environmental signalling: What embryo and evolution teach us about endocrine chemicals? Endocrinology Reviews 22: 319-41.

Meenakshi, Sharon, P, Bhawana M, Anita S, Gothecha VK. 2012. A short review on how pesticides affect human health. International Journal of Ayurvedic Herb Medicine 2(5): 935-946.

Melchiorri D, Reiter R, Sewerynek E, Hara M, Chen L, Histico G. 1996. Paraquat toxicity and oxidative damage. Reduction by melatonin. Biochemical Pharmacology 39: 1095-1099.

Milatovic D, Gupta R C and Aschner M. 2006.Acetylcholinesterase toxicity and oxidative stress. Science World Journal 6: 295-310.

Mnif W, Hassine A I H, Bouaziz A, Bartegi A, Thomas O, Roig B. 2011. Effect of endocrine disruptor pesticides: a review. International Journal of Environment Research and Public Health 8: 2265-2203.

Muniz J F, Cualey L, Scherer J, Lsarev M, Kow Y W and Kisby G E. 2008. Biomarker of oxidative stress and DNA damage in agricultural workers: A pilot study. Toxicology and Applied Pharmacology 227: 97-107.

Nayak S, Sahoo A, Kolanthasamy E, Rao K. 2020. Retrieved from .26832/aesa-2020-edcrs-03.

Ngoula F, Ngouateu O B, Kana J R, Defang H F, Watcho P, Kamtchouing P. 2012. Reproductive and developmental toxicity of insecticides. In: Perveen F, editor. Insecticides, Advances in Integrated Pest Management. UK: Intech Open. 429-457 pp. ISBN: 978-953-307-780-2.

Pandey A K, Nagpure N S, Trivedi S P. 2018. Genotoxicity assessment of pesticide profenofos in freshwater fish Channapunctatus (Bloch) using comet assay and random amplified polymorphic DNA (RAPD). Chemosphere 211: 316-323.

Pan-Germany, 2012.Pesticide and health hazards. Facts and figures. 1-16 (www.pan

Pirsaheb M, Limoee M, Namdari F, Khamutian R. 2015.Organochlorine pesticides residue in breast milk: a systematic review. Medical Journal of The Islamic Republic of Iran 29: 228.

Richter E D. 2002. Acute human pesticide poisonings. Encyclopedia of Pest Management. pp. 3-6.

Samada L H, Tambunan U S F. 2020. Biopesticides as promising alternatives to chemical pesticides: A review of their current and future status. On Line Journal of Biological Sciences 20(2): 66-76.

Savary S, Willocquet L, Pethybridge S J, Esker P, Mc Roberts N, Nelson A. 2019. The global burden of pathogens and pests on major food crops. Nature Ecology and Evolution 3(3): 430-439.

Scandalios J G. 2005. Oxidative stress: Molecular perception and transduction of signals triggering antioxidant gene defenses. Brazilian Journal of Medical Biological Research38: 995-1014.

Schettler T, Solomon G, Kaplan J, Valenti M. 2003.Generations at Risk: How Environmental toxicants may affect reproductive health in California Brisbane, CA: George Lithograph.

Shalaby M A, El Zorba H Y, Ziada R M. 2010. Reproductive toxicity of methomyl insecticide in male rats and protective effect of folic acid. Food and Chemical Toxicology. 48: 3221-3226.

Sparks T C, Nauen R 2015. IRAC: Mode of action classification and insecticide resistance management.

Sharpe R M. 2006. Pathways of endocrine disruption during male sexual differentiation and masculinisation. Best Practices of Research and Clinical Endocrinology Metabolism 20: 91-110.

Sogorb M A, Vilanova E. 2002. Enzymes involved in the detoxification of organophosphorus, carbamate and pyrethroid insecticides through hydrolysis. Toxicology Letters 128: 215-228.

Soloneski S, Kujawski M, Scuto A, Larramendy M L. 2015. Carbamates: a study on genotoxic, cytotoxic, and apoptotic effects induced in Chinese hamster ovary (CHO-K1) cells. Toxicology In Vitro 29: 834-44.

Sparks T C, Nauen R. 2015. IRAC: Mode of action classification and insecticide resistance management, Pesticide Biochemistry and Physiology 121: 122-28

Swanson N L, Leu A, Abrahamson J, Wallet B. 2014. Genetically engineered crops, glyphosate and the deterioration of health in the United States of America. Journal of Organic Systematics 9: 6-37.

Tabb M M, Blumberg B. 2006. New modes of action for endocrine-disrupting chemicals. Molecular Endocrinology 20: 475-482. Thongprakaisang S, Thiantanawat A, Rangkadilok N, Suriyo T, Satayavivad J. 2013. Glyphosate induces human breast cancer cells growth via estrogen receptors. Food and Chemical Toxicology 59: 129-36.

Tapi L R, Leyva A, Laynez F, Santed F S. 2005. Chronic neurosycological sequelea of cholinesterase inhibitors in the absence of structural brain damage: Two cases of acute poisoning. Environment Health Perspectives 113(6): 762-66.

Tiemann U. 2008. In vivo and invitro effects of the organochlorine pesticides DDT, TCPM, methoxychlor, and lindane on the female reproductive tract of mammals: a review Reproductive Toxicology 25: 316-26.

Tudi M, Ruan H D, Wang L, Lyu J, Sadler R, Connell D, Chu C, Phung D T. 2021. Agriculture development, pesticide application and its impact on the environment. International Journal of Environmental Research and Public Health 18(3): 1112.

Verma R S, Mehta A, Srivastava N. 2007. In vivo chlorpyrifos induced oxidative stress: Attenuation by antioxidant vitamins. Pesticide Biochemistry and Physiology 88: 191-196.

Vinggaard A M, Hnida C, Breinholt V, Larsen J C. 2000. Screening of selected pesticides for inhibition of CYP19 aromatase activity in vitro. Toxicology In Vitro 14: 227-234.

Wesseling C, Keifer M, Ahlbom A, McConnell R, Moon J D, Rosenstock L. 2002. Long-term neurobehavioral effects of mild poisonings with organophosphate and n-methyl carbamate pesticides among banana workers. International Journal of Occupational Environment Health 8: 27-34.

Yousaf M I, Awad T I Mohammad E H. 2006. Deltamethrin- induced oxidative damage and biochemical alterations in rat and its attenuation by Vit. E. Toxicology 227: 240-47.